Nattokinase: Fibrinolytic Properties & Cardiovascular Research

Nattokinase is a serine protease produced during the fermentation of soybeans into natto, a traditional Japanese food. It was first identified in 1987 by Dr. Hiroyuki Sumi, who discovered its potent ability to dissolve fibrin — the structural protein in blood clots.

Fibrinolytic Properties

Nattokinase works through multiple mechanisms: direct degradation of fibrin, activation of the body's own fibrinolytic enzymes (pro-urokinase and tissue plasminogen activator), and inactivation of plasminogen activator inhibitor-1 (PAI-1). This multi-pathway approach makes it more interesting than a simple clot-dissolving agent.

Cardiovascular Research

Human studies have shown nattokinase can reduce blood pressure, decrease fibrinogen levels, and improve blood flow parameters. A notable Japanese trial found that nattokinase supplementation reduced progression of atherosclerotic plaque. However, larger and longer-term studies are still needed.

Nattokinase is distinct from vitamin K2, which is also abundant in natto. While K2 affects calcium metabolism and (indirectly) arterial health, nattokinase works on the fibrinolytic system. Natto provides both.